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The proportion of children and adolescents prescribed antipsychotics in English general practice doubled from 0.06% to 0.11% between 2000 and 2019, find researchers at The University of Manchester青瓜视频檚 Centre for Women青瓜视频檚 Mental Health.

The drugs, which have a tranquillising effect, are frequently used in adults to treat major mental illness, such as schizophrenia.

However, they can be associated with substantial side-effects such as sexual dysfunction, infertility, and weight gain leading to diabetes.

The National Institute for Health and Care Excellence has approved the use of some antipsychotics in under 18青瓜视频檚 with psychosis or with severely aggressive behaviour from conduct disorder

However the study, published in the Lancet Psychiatry, suggests they are prescribed for an increasingly broad range of reasons - the most common being autism.

The team examined primary care records of 7.2 million children and adolescents, aged 3 to 18, registered at selected English General Practices over the period 2000 to 2019.

The overall percentage who were prescribed antipsychotics was relatively small 青瓜视频� 0.06% in 2000 and 0.11%  in 2019.

However, the increasing use of antipsychotics is a cause for concern, argue the researchers, given that their safety in children, who are still rapidly developing, has not been established.

The study also found that:

• Boys and older children 青瓜视频� aged 15 to 18 青瓜视频� were more likely to be prescribed antipsychotics than girls and younger children; however, the increasing trends were evident in all groups.
• The older class of antipsychotics, that may be associated with extrapyramidal side effects such as movement disorders, were more commonly prescribed in more deprived areas.

Dr Matthias Pierce, senior research fellow at the University of Manchester青瓜视频檚 Centre for Women青瓜视频檚 Mental Health jointly lead the study.

He said: 青瓜视频淭his study demonstrates a concerning trend in antipsychotic prescribing in children and adolescents. We do not think the changes in prescribing necessarily relate to changes in clinical need; rather, it may be more likely to reflect changes in prescribing practice by clinicians.

青瓜视频淗owever, this study will help clinicians to evaluate the prescribing of antipsychotics to children more fully and will encourage them to consider better access to alternatives.青瓜视频�

Senior author, Professor Kathryn Abel from The University of Manchester said: 青瓜视频淎ntipsychotic medications continue to have a valuable role in the treatment of serious mental illness. These findings represent a descriptive account of antipsychotic prescribing to children and adolescents in the UK today and provide a window onto current practice.

青瓜视频淚t is notable, and relevant to the current discourse, that we report inequities in prescribing as a result of deprivation levels; and that the indications for which approvals are available are no longer the commonest reason these medications are being prescribed. Broadening use of antipsychotics in developing young people begs questions about their safety over time and demands more research on this topic.青瓜视频�

The study is available at this

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